A major disadvantage of postoral delivery is that blood flow from the intestine leads into the portal vein which flows directly to the liver. This leads to the phenomenon of first pass clearance, in which drug is metabolized and/or excreted by the liver before it can reach the general circulation. Other routes of administration circumvent […]
As defined in FDA guidance, bioavailability is “the rate and extent to which the active drug ingredient or therapeutic moiety is absorbed from a drug product and becomes available at the site of action.” While the definition appears sufficient, there a level of ambiguity in the scientific literature has led some people to confuse oral […]
For many years, pharmaceutical and academic scientists have sought ways to deliver protein and peptide therapeutics by the oral route. Many encouraging results from animal experiments have been published and offer insights into the prospects of translating these discoveries to delivery systems suitable for human use. To date, the only accepted delivery systems for macromolecules […]
No one doubts the utility of computers for simple things like aerospace engineering and weather prediction, but pharmacokinetics is not rocket science. It is far more complex. Computers are indispensible for analyzing PK data, but how well can they do at actually predicting drug delivery and disposition? Some people are in love with computer models, […]
As all parents of young children know, toddlers in particular are at increased risk for poisoning and mischievous behavior of all kinds. All toddlers (and especially 2-year-olds) like to investigate their surroundings whenever possible, a reality that sometimes leads them to eat, drink, touch, or breathe substances that can be toxic. Pediatrics jobs often involve […]
In today\’s world if you are 50 plus, alone and stressed then you shouldn\’t fear of your age and in fact, think of this time in life like another chance for transformation and growth. Let us discuss some dating strategies, you could have to look for love. The nastiest thing you could bring upon yourself […]
Do you find yourself 50 plus, alone and worried? If you are then you need not keep worrying about your age and probably, look at this time of your life as another opportunity for transformation and development. Let us discuss some dating tactics, you might choose to find love. The most harmful thing you could […]
These days if you are over 50, single and distressed then you shouldn\’t stress over your age and actually, think about this period in life as another chance for changeover and improvement. Listed below are some dating strategies, you could have to seek love. The worst disservice you can cause to yourself if you\’re dating […]
This blog post is for those who\’re over 50, single and apprehensive. Actually now, you do not need to fear of your age and in fact, think about this period in life like a new chance for change and success. Allow me to share a few dating secrets, you can try to hunt for love. […]
This blog post is for those who are over 50, single and apprehensive. Believe it or not nowadays, you must not keep worrying about your age and in fact, consider this moment in your life like another chance for transition and success. Let\’s consider a few dating steps, you may use to seek romance. The […]
