Injuries are part of life and whenever you are struggling with one, the legal expertise that is close by could serve you. Using a bit of specific study online you can guarantee that you have a good reason to register a compensation case. They learn about your problem and assist in standing for you in […]

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Your car is more than just a vehicle to get you from Point A to Point B – it’s your car. You want to be comfortable while you’re driving it and you also want it to look good. While there are many aftermarket options you can pick up to trick your whip both on its […]

Owning a vehicle is an investment, and to protect that investment a good vehicle owner knows that proper maintenance and repairs will help extend the life of their car, truck, or SUV. For this reason, finding a good mechanic is as essential as having a trusted family doctor: a good mechanic is someone that you […]

Anyone who has ever taken a medicine is aware of the balance between efficacy and adverse effects. Efficacy cannot be obtained unless the dose is high enough, but if the dose is too high, adverse effects will kick in and may outweigh the positive impact of the drug. To assure that the patient’s dose is […]

A major disadvantage of postoral delivery is that blood flow from the intestine leads into the portal vein which flows directly to the liver. This leads to the phenomenon of first pass clearance, in which drug is metabolized and/or excreted by the liver before it can reach the general circulation. Other routes of administration circumvent […]

For many years, pharmaceutical and academic scientists have sought ways to deliver protein and peptide therapeutics by the oral route. Many encouraging results from animal experiments have been published and offer insights into the prospects of translating these discoveries to delivery systems suitable for human use. To date, the only accepted delivery systems for macromolecules […]

As defined in FDA guidance, bioavailability is “the rate and extent to which the active drug ingredient or therapeutic moiety is absorbed from a drug product and becomes available at the site of action.” While the definition appears sufficient, there a level of ambiguity in the scientific literature has led some people to confuse oral […]

No one doubts the utility of computers for simple things like aerospace engineering and weather prediction, but pharmacokinetics is not rocket science. It is far more complex. Computers are indispensible for analyzing PK data, but how well can they do at actually predicting drug delivery and disposition? Some people are in love with computer models, […]